Respiratory and immunologic evaluation of isocyanate exposure in a new manufacturing plant



Publisher: U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Publisher: For sale by the Supt. of Docs., U.S. G.P.O. in Morgantown, W. Va, Washington, D.C

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Published: Pages: 152 Downloads: 614
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Subjects:

  • Toluene -- Toxicology,
  • Toluene -- Physiological effect

Edition Notes

Occupational asthma is defined as a disease characterized by variable airflow limitation and/or bronchial hyperresponsiveness due to causes and conditions attributable to a particular working environment and not to stimuli encountered outside the workplace. 12 x 12 Bernstein, IL, Bernstein, DI, Malo, J-L, Definition and classification of asthma., Asthma in the workplace., Bernstein, IL, Chan Cited by: Publ by AIChE, New York, NY, USA Pap 72a, 6p CODEN: ACENC9 E.I. Conference No.: Language: English On December 3, , a leak of over 25 tons of toxic methyl isocyanate from a chemical plant in Bhopal, India, killed over people. Immunological evaluation of four arc welders exposed to fumes from ignited polyurethane (isocyanate) foam: antibodies and immune profiles. The mortality of 1, male workers employed at least 30 days in in a resins-manufacturing plant was examined. Ambient measurements taken in the plant between and documented a potential for exposure to levels of formaldehyde as high or greater than mg/cu m. Vital status was ascertained for % of the cohort members.

This banner text can have markup.. web; books; video; audio; software; images; Toggle navigation. The permitted duration of exposure for any worker at any sound level indicated in the preceding table is reduced by one half, effective from a date to be determined by a regulation made in accordance with section of the Act respecting occupational health and safety (chapter S). O.C. , s. Exposure Assessment Undertaken to Support the Evaluation of the HAP Definition of -Glycol Ethers- This document describes an exposure assessment for surfactant alcohol ethoxylates and their derivates to address U.S. Environmental Protection Agency`s (U.S. EPA`s) classification of -glycol ethers- as a single class of hazardous air pollutants. lation is not a contraindication for bronchoscopy. .. from the strong electromagnetic field. .. Electromagnetic.

Recommendations 1- Allergic rhinitis is a major chronic respiratory disease due to its: prevalence, - impact on quality of life, - impact on work/school performance and productivity, - economic burden, - links with asthma. 2- In addition, allergic rhinitis is associated with sinusitis and other co-morbidities such as conjunctivitis. 3- Allergic rhinitis should be considered as a risk factor. You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them.   Respiratory Irritants. Respiratory irritants cause non-specific inflammation of the lung after being inhaled. These substances, their sources of exposure, physical and other properties, and effects on the victim are outlined in Table 1. Irritant gases tend to be more water soluble than gases more toxic to the lung parenchyma. Historical Archive of Endowment Fund Award Recipients The SOT Endowment Fund is a family of funds that support SOT programs and members. Many of the funds sponsor awards designed to encourage, assist, and highlight toxicology research and toxicologists.

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[Hans Weill; National Institute for Occupational Safety and Health. Division of Respiratory Disease Studies.;].

Get this from a library. Respiratory and immunologic evaluation of isocyanate exposure in a new manufacturing plant. [Hans Weill; Tulane University.

School of Medicine.; National Institute for Occupational Safety and Health. Division of Respiratory Disease Studies.;]. Environmental Medicine: Integrating a Missing Element into Medical Education. Washington, DC: The National Academies Press. doi: / Butcher BT, Dharmarajan V, et al.

(): “Respiratory and immunologic evaluation of isocyanate exposure in a new manufacturing plant.” NIOSH Publication No. 81– NIOSH Technical Report. NIOSH []. Technical report: respiratory and immunologic evaluation of isocyanate exposure in a new manufacturing plant.

DHHS (NIOSH) Publication No. Cincinnati, OH: U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, NIOSH. McKay RT, Brooks SM [].

Isocyanates were discovered by Wurtz in and their uses in polyurethane began in The isocyanates and abbreviations that will be used in this presention are shown in Table I. Abbreviations of Isocyanates Table I There weremetric tons of TDI andmetric tons of MDI produced innot including production in countries having central economic planning (Table II).

These. PDF | Human exposure to toluene diisocyanate (TDI) occurs mainly through inhalation of vapors in occupational settings where TDI is produced or used, | Find, read and cite all the research you.

related to isocyanate skin exposure and its role. polyurethane foam manufacturing plant. Arch Environ. Health 57(3)– Pulmonary and immunologic evaluation.

A meta description is an HTML tag in the HTML code of your website, which allows you to customize a section of text that describes the page itself. It plays a role in how your page is seen by search engine crawlers, and how it appears in SERPs.

Dermal and inhalation exposure to methylene bisphenyl isocyanate (MDI) is associated with respiratory sensitization and occupational asthma. However, limited research has been performed on the quantitative evaluation of dermal and inhalation exposure to MDI in occupationally exposed by: Veterans at Risk: The Health Effects of Mustard Gas and Lewisite () Chapter: J.

Examination of the Effects of Certain Acute Environmental Exposures on Future Respiratory Health Consequences. Respiratory And Immunologic Evaluation Of Isocyanate Exposure In A New Manufacturing Plant Respirators: Your TB Defense / TB Respiratory Protection: Administrator's Review (DVD: D; VHS: V) (Video).

Introduction. Toluene diisocyanate (TDI) is a highly reactive compound used in the production of polyurethane foams and other industrial products, such as elastomers, coatings, and adhesives (Allport et al.,Collins,International Agency for Research on Cancer (IARC),National Toxicology Program (NTP), ).The two most commonly used isomers of TDI are 2,4-TDI and 2,6-TDI Cited by: 4.

Even though aeroallergen exposure is more complex than exposure to toxic materials, new immunologic methodologies and the use of personal sampling have made possible the measurement of high-molecular-weight allergens in the workplace.

Detailed information on this topic has been published (, ). In addition, data obtained by quantified. Background: Diisocyanate chemicals are leading causes of occupational asthma (OA). Methods: We conducted a cross-sectional study of workers exposed to diphenylmethane diisocyanate (MDI) in a methane mold plant that had been designed to minimize MDI exposure (levels were maintained below ppm and were continuously monitored).

All participants were screened by questionnaire and Cited by:   Types of Disease. Chemical agents are the main cause of occupational skin diseases, and dermal exposure to chemicals can result in a wide range of other adverse health effects.

17 In general, there are three types of chemical–skin interactions of occupational concern: direct skin effects, immune-mediated skin effects, and systemic effects. Direct skin effects occur when exposure to the Cited by:   With respect to non-cancer effects, comparison of the critical effect level for chronic non-neoplastic effects via inhalation in humans (i.e.

14 µg/m 3) and the conservative upper-bounding exposure estimate via inhalation for TDI ( µg/m 3), in the vicinity of a plant using TDI, results in a margin of exposure of approximately   Respiratory And Immunologic Evaluation Of Isocyanate Exposure In A New Manufacturing Plant 1.

Teratologic Assessment Of Butylene Oxide, Styrene Oxide, And Methyl Bromide 1. Work Practices Guide For Manual Lifting (Revised: 9. An Evaluation Of Engineering Control Technology For Spray Painting 1.

Long- Term Mortality Experience Of Steelworkers 1. Vapor-phase 4-chlorophenyl isocyanate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 7 days(SRC), calculated from its rate constant of X cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3).

The prevalence of acute respiratory symptoms (89%) and their persistence among this cohort are more consistent for a significant exposure to toxic fire gases rather than exposure to TDI.

In response to exposure of TDI liquid, there appeared to be a large amount of water sprayed on the tanks and perhaps pooling on the floor from fighting the fire. Phillip I. Harber is a Pulmonologist in Tucson, AZ.

Find Dr. Harber's phone number, address and more. Toluene 2,6-diisocyanate is a toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 6 relative to the methyl group on the benzene ring.

It has a role as a hapten and an allergen. Classic OA refers to new-onset OA associated with exposure followed by an immunologic response to a high- or low-molecular-weight sensitizer. Although one important investigation of an occupational lung clinic found that cases meeting criteria for RADS had a ratio to classic asthma (27), two more recent clinical series (, ) have.

Asthma is common among adults of working age and affects 5–10% of the population worldwide. Occupational asthma has become a common work related respiratory disorder in the industrialised world.1 Blanc and Toren have shown that 9% of cases of adult asthma—including principally new onset asthma and, much more rarely, reactivation of pre-existing asthma—are Cited by: Ski manufacturing.

Brubaker RE, et al. Evaluation and control of a respiratory exposure to 3-(dimethylamine) propylamine. J Occup Med ; Sargent EV, et al. Respiratory effects of occupationa1 exposure to an epoxy resin system. Arch Environ Health ; 4-Methylmorpholine. 4,4-methylene-bismorpholine.

NNM. Fur dying. Bernstein D. I., Patterson R., Zeiss C. Clinical and immunologic evaluation of trimellitic anhydride and phthalic anhydride exposed workers using a questionnaire with comparative analysis of enzyme-linked immunosorbent and radioimmunoassay studies.

Journal of Allergy and Clinical Immunology. ; – [PubMed: ]. Abstract. DAN is a novel derivatizing agent for isocyanate sampling which targets total reactive isocyanate group (TRIG). Field evaluations have been conductedCited by: 1. With gaseous exposure, a more equal exposure over the large surface area of the respiratory organ is to be expected.

These phenomena may have mechanistic and biological implications, but certainly determine exposure assessment approaches, the interpretation of exposure measurements and the evaluation of exposure-response by: 5.

Isocyanate Exposure Intervention Study in Body Shops, CDC 1 R01 OH,Co-I (Y. Liu, Principal Investigator) Natural History of Chronic Beryllium Disease, Brush-Wellman Contract,Principal Investigator. The Manufacturing sector has the highest number of cases (26,) and the second highest reported incidence ( per ,) of occupational skin diseases among major industries.

67 This sector includes a number of professions, including printing, petroleum and coal products manufacturing, chemical manufacturing, plastic and rubber products Cited by: Recognition that workplace exposures may be associated with acute ill effects on the respiratory system is not new.

Ramazzini in identified plant dusts as culprits; he noted, of the men who sift and measure grain, that “the throat, lungs and eyes are keenly aware of serious damage,” and of the men who card flax and hemp, that they “find it very irksome for a foul and poisonous dust Cited by:.

A literature search conducted for the years to identified a quantitative risk assessment of health risks (including cancer) associated with occupational exposure to arsenic () and a study of the exposure-response curve for respiratory cancer in copper .The earthworm was the most sensitive species to 4,4'-MDA, particularly with from the long-term exposure.

In addition, two plant species were tested, oats and lettuce, and results from these studies suggested a similar sensitivity between the two plant species to 4,4'-MDA exposure.Respiratory irritants often worsen symptoms in workers with pre-existing asthma (i.e., WAA) and, at high exposure levels, can cause new onset of asthma (termed reactive airways dysfunction syndrome (RADS) or irritant-induced asthma) (Brooks, Weiss and Bernstein ; Alberts and Do Pico ).

OA may occur with or without a latency period.